Corsidus understands the importance of early safety assessments to enable a drug to advance in development. One third of failures in drug development are due to unacceptable toxicity levels. It is critical that compounds undergo the most comprehensive yet targeted safety and toxicology studies early in development to identify any potential issues that may affect investment or development decisions.
Corsidus will guide you through the selection and design of these crucial in vitro and in vivo safety pharmacology and toxicology studies. We will assist you in establishing appropriate measures to monitor and fully evaluate any potential adverse effects of your drug prior to embarking on larger scale and more costly preclinical studies.
Corsidus will assist you in selecting and conducting appropriate assays from the following pharmacology and toxicology studies:
In Vitro assays
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Cytotoxicity Assay
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Bacterial mutation (Ames)
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Genotoxicity assessments
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Metabolic profiling and parent drug stability
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Hemolysis of red blood cells
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hERG channel inhibition
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Cardiac action potential assays
GLP safety studies in rodent and non-rodent species
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Maximum tolerated dose
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Repeat dose toxicology studies
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Central nervous system studies
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Assessment of effects on respiratory function
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Full cardiovascular profiling in telemetered animals
To obtain additional information on our Safety and Toxicology programs please call Corsidus at
1-888-367-5212.
